Britain's Ryan Peniston was unable to back up his first Wimbledon win as he was outplayed by wily American Steve Johnson in the second round.
But he was not at his best in a 6-3 6-2 6-4 defeat by 93rd-ranked Johnson.
Johnson could meet Cameron Norrie in the third round if the British number one beats Spain's Jaume Munar later.
Peniston, ranked 135th in the world, has been in terrific form coming into the grass-court Grand Slam, reaching the quarter-finals at Eastbourne, Queen's and Nottingham.
As he walked off the singles court for the final time in a successful British summer, the home fans rose to their feet to applaud his achievements.