Defending champion Andy Murray was knocked out of Wimbledon in the quarter-finals by American 24th seed Sam Querrey on Centre Court.
Querrey, 29, won 3-6 6-4 6-7 (4-7) 6-1 6-1 to become the first American to reach a Grand Slam semi-final since Andy Roddick at Wimbledon in 2009.
The Briton, 30, led by a set and a break but lost 12 of the last 14 games as he appeared to struggle physically.
The defeat means Novak Djokovic could overtake Murray as world number one.
Second seed Djokovic, who plays Tomas Berdych later on Wednesday, needs to win the title to return to the top of the rankings.