The US Open will be held without fans from 31 August to 13 September, after plans were approved by governor of New York Andrew Cuomo.
The Grand Slam will be held at Flushing Meadows, despite some players voicing concerns about travelling to New York.
There have been no professional tennis events since March because of the coronavirus pandemic.
"We can showcase tennis as the ideal social distancing sport," US Tennis Association chief Mike Dowse said.
Cuomo wrote that "extraordinary precautions" would be in place to protect players, including coronavirus testing and extra locker room space.