Britain's former US Open champion Andy Murray will play Japan's Yoshihito Nishioka in the first round of the behind-closed-doors Grand Slam.
Murray, 33, is playing singles at a major for the first time since the 2019 Australian Open after injury problems.
British number one Johanna Konta plays her compatriot Heather Watson, while Kyle Edmund could face men's top seed Novak Djokovic in round two.
The Grand Slam starts on Monday at Flushing Meadows in New York.
A host of star names, including defending champions Rafael Nadal and Bianca Andreescu, are not playing because of the coronavirus pandemic.