Andy Murray's hopes of reaching the last 16 of a major for the first time since 2017 were crushed by Italy's Matteo Berrettini at the US Open.
Fellow Briton Jack Draper is also out after having to retire injured from his match against Russia's Karen Khachanov.
Draper, 20, levelled at one-set all, and served for the third set, but had to stop when trailing 6-5.
Murray and Draper were among the four British men to reach the third round at Flushing Meadows, setting a new record for the nation at the US Open.
British number one Cameron Norrie, seeded seventh, and 20th seed Dan Evans make up the quartet and play their last-32 matches on Saturday.