Britain's Dan Evans was outclassed by second seed Daniil Medvedev as the dominant Russian reached the US Open quarter-finals.
Evans, who had been seeking to reach his first Grand Slam quarter-final, lost 6-3 6-4 6-3 to the 2019 runner-up.
Medvedev has not dropped a set at this tournament and the British number one never got close to changing that under the roof on Arthur Ashe Stadium.
The world number two will play Dutch qualifier Botic van de Zandschulp next.
Evans beaten but takes home positives
By reaching the fourth round in New York, Evans had matched his previous best Grand Slam performance and is set to reach a career-high ranking inside the world's top 25 when the list is next published after the US Open.