Former champion Andy Murray will face Greek third seed Stefanos Tsitsipas in the first round of the US Open.
Top seed Novak Djokovic, bidding for a record 21st Grand Slam men's singles title and a clean sweep of the majors in 2021, starts against a qualifier.
Ashleigh Barty, the women's world number one, faces Vera Zvonareva, while Britain's top-ranked woman Johanna Konta plays Kristina Mladenovic.
The final Grand Slam of the season starts in New York on Monday.
But the tournament - which is the first major since the coronavirus pandemic to be held with a 100% crowd throughout - will be without a host of star names.