World number ones Novak Djokovic and Naomi Osaka will seek to defend their titles at a US Open that Britain's Andy Murray has chosen to miss.
The Scot, who had hip surgery in January, had planned to play doubles but is focusing on singles elsewhere.
In his absence, the country's number ones Johanna Konta and Kyle Edmund will carry British hopes in New York.
Roger Federer and Serena Williams will be again chasing records at the final Grand Slam tournament of the year.
Swiss great Federer, 38, is seeking a record sixth men's US Open singles title that would also make him the oldest men's Grand Slam singles champion in the Open era.