Former champions Rafael Nadal and Novak Djokovic will bid to set up a 53rd meeting with victories in the US Open semi-finals on Friday.
The pair have met more than any two men in the Open era and could meet for a fourth time in a final in New York.
Spanish defending champion Nadal faces Argentine third seed Juan Martin del Potro in the last four as he aims for an 18th Grand Slam title.
Two-time winner Djokovic follows against Japan's Kei Nishikori.
Nadal and 2009 US Open champion Del Potro have met twice in Grand Slams this year, at the French Open and Wimbledon with Nadal winning on both occasions.