Andy Murray will play Australia's James Duckworth when he makes his return to Grand Slam tennis after a 14-month absence with a hip injury.
The former world number one, now ranked 378th, could play third seed Juan Martin del Potro in the third round.
Kyle Edmund, his replacement as British number one, faces Italy's Paolo Lorenzi, while Cameron Norrie meets Australian Jordan Thompson.
Johanna Konta has a tough match against French sixth seed Caroline Garcia.
British number one Konta, 27, has dropped to 46 in the rankings after a year in which she has struggled to find consistency.