Johanna Konta and Kyle Edmund will carry British hopes on the opening day of the US Open on Monday.
Edmund, ranked 85th, opens play on court five against France's 13th seed Richard Gasquet at 16:00.
Konta, seeded 13th, plays American Bethanie Mattek-Sands on the Grandstand court at around 00:00 BST on Tuesday.
Novak Djokovic, Rafael Nadal and Angelique Kerber also play on day one, while Andy Murray is among six Britons scheduled for day two.
The Scot, seeded second, will play Czech Lukas Rosol in the second night match at around 02:00 on Wednesday.
Heather Watson, Naomi Broady, Laura Robson, Dan Evans and Aljaz Bedene complete the British singles contingent.