Dan Evans beat Rajeev Ram to become the third Briton into the second round of the US Open, but compatriot Heather Watson lost her first-round match.
British number two Evans, 26, won 6-2 4-6 7-5 6-1 to join Kyle Edmund and Johanna Konta in the last 64.
Watson, 24, lost 6-2 7-5 to Dutch qualifier Richel Hogenkamp.
World number 73 Watson, who appeared to be struggling with a back injury, has failed to reach the second round at Flushing Meadows in six attempts.
Watson, the British number two, was in tears after losing the first set in 32 minutes before being massaged by a trainer and given pills by a doctor.