Jack Draper's run at the Cincinnati Open ended in the quarter-finals as he was beaten in straight sets by Denmark's Holger Rune.
The British number one had come from a set down to win his previous two matches, but the 22-year-old was unable to repeat the feat against the 15th seed.
Rune won 6-4 6-2 after taking his chance on the only break point of the first set, which put him 3-2 up.
The Dane broke again at the start of the second set and saved three break points, seizing his only other opportunity on Draper's serve in the 11th game before serving out for victory.