Wimbledon champion Novak Djokovic came from a set down to beat Adrian Mannarino and move into the third round in Cincinnati.
The 13-time Grand Slam winner defeated his French opponent, the world number 25, 4-6 6-2 6-1.
Serbia's Djokovic, ranked 10 in the world, will next play Bulgarian Grigor Dimitrov or German Mischa Zverev.
Earlier on Wednesday, Croatia's Marin Cilic beat Marius Copil of Romania 6-7 (4-7) 6-4 6-4.
And Robin Haase of the Netherlands beat Germany's Alexander Zverev 5-7 6-4 7-5.