Great Britain's Dan Evans is out of the Madrid Open after a straight-sets defeat by Spain's Bernabe Zapata Miralles.
Zapata Miralles, ranked world number 42, will face Russian qualifier Roman Safiullin in the third round of the clay-court tournament.
British number one Cameron Norrie is in action later on Saturday against Japan's Yosuke Watanuki.
Evans would have hoped to build on some of the momentum gathered at the Barcelona Open, where he reached the semi-final but was beaten in straight sets by top seed Carlos Alcaraz, 19.
Elsewhere, Daniil Medvedev beat Italy's Andrea Vavassori 6-4 6-3 to progress to the round of 32, while Serbia's Dusan Lajovic secured a dramatic win over world number nine Felix Auger-Aliassime, winning 6-2 3-6 7-6 (7-5).