Australian Open champion and world number five Madison Keys is out of the Miami Open after a shock 6-4 6-2 defeat to Filipina wildcard Alexandra Eala.
The 19-year-old, who won the US Open girls singles title in 2022, is the first woman from the Philippines to beat a top-10 opponent since the professional Open era began 1975.
The world number 140 has now knocked out two Grand Slam champions in Florida, having beaten 2017 French Open winner Jelena Ostapenko in the second round.
"Growing up it was tough. You didn't have anyone from where you're from to pave the way," said Eala, who has been based to the Rafael Nadal academy in Mallorca since she was 13.