MELBOURNE, Australia — John Isner hit more aces than his opponent, 47-40. He delivered more total winners and finished with more overall points, too. What Isner failed to do for the first time in his career was beat an American foe at a Grand Slam tournament, and now the highest-ranked man from the U.S. is gone from the Australian Open.
Reilly Opelka, ranked just 97th, earned his first victory in a main-draw match at a major by edging Isner in four tiebreakers 7-6 (4), 7-6 (6), 6-7 (4), 7-6 (5).
Isner was seeded No. 9, was a semifinalist at Wimbledon last year and had been 9-0 in all-U.