Novak Djokovic suffered his third straight defeat as Dutch lucky loser Botic van de Zandschulp pulled off a shock victory in the second round at Indian Wells.
The seventh seed lost 6-2 3-6 6-1 to the world number 85 in a subdued performance.
Since memorably beating Carlos Alcaraz in the Australian Open quarter-finals, the 37-year-old has lost to Alexander Zverev in the Melbourne semi-finals, Matteo Berrettini in Doha and now Van de Zandschulp.
The 24-time Grand Slam champion won only one title last year - albeit the elusive Olympic gold he had always coveted - and failed to win a major for the first time since 2017.