Novak Djokovic suffered his earliest exit at the Italian Open since 2013 when he was beaten by rising Danish star Holger Rune in the quarter-finals.
The Serb top seed, who turns 36 next week, was beaten 6-2 4-6 6-2 by 20-year-old Rune on the Rome clay.
Djokovic was bidding for his seventh title in the Italian capital as he prepares for the French Open on 28 May.
Seventh seed Rune will play Norwegian fourth seed Casper Ruud in the semi-final.
Djokovic's preparations for the French Open have been disrupted by injury, having missed the recent Madrid Open with an elbow problem and returning to the court in Rome as he looked to build up form and fitness.