British number three Dan Evans lost 6-7 (4-7) 6-3 6-3 against three-time Grand Slam champion Stan Wawrinka in their first-round match at Indian Wells.
Evans, 28, back inside the world's top 100 after a drugs ban, saved three set points before taking the opening set.
World number 40 Wawrinka levelled and broke in the eighth game of the decider to win in two hours eight minutes.
Earlier, British women's number one Johanna Konta beat Hsieh Su-Wei of Taiwan 6-0 6-2 to reach round three.
World number 45 Konta won the first eight games and saved three break points when serving at 3-2 in the second.