British number two Cameron Norrie lost in straight sets in the first round to Canada's 18-year-old world number 58 Felix Auger-Aliassime in Indian Wells.
In the first meeting between the pair, the Canadian teenager took the first set 6-3 in 33 minutes.
Auger-Aliassime, who reached his first ATP final at last month's Rio Open, raced through the second 6-2 to wrap up the match in 62 minutes.
He now faces Stefanos Tsitsipas, who won the Marseille title last month.
British number one Kyle Edmund, who received a bye, awaits the winner of the match between Nicolas Jarry of Chile and American Frances Tiafoe.