Former champion Jelena Ostapenko suffered a shock French Open second-round defeat by tournament debutant Peyton Stearns.
Latvian 17th seed Ostapenko, the winner at Roland Garros in 2017, lost 6-3 1-6 6-2 to the American.
She became the 15th women's seed to be knocked out as the second round got under way in Paris on Wednesday.
Stearns, 21, is playing in her first overseas Grand Slam after making her major debut at last year's US Open.
Her first-round victory over doubles world number one Katerina Siniakova was her first at a Grand Slam.
She will face Russian ninth seed Daria Kasatkina or Marketa Vondrousova of the Czech Republic in the third round.