Daniil Medvedev and Stefanos Tsitsipas suffered surprise fourth-round exits on a day of shocks in the men's draw at the French Open.
World number two Medvedev was thrashed 6-2 6-3 6-2 by Croatian Marin Cilic in a one-sided evening session.
Fourth seed Tsitsipas lost in four sets as teenager Holger Rune reached a maiden Grand Slam quarter-final.
The Dane, 19, punished a lacklustre display from the 2021 Roland Garros runner-up to triumph 7-5 3-6 6-3 6-4.
Rune meets Casper Ruud in the last eight after the Norwegian also won in four sets, beating Poland's Hubert Hurkacz.