Defending champion Rafael Nadal could meet Novak Djokovic in the French Open semi-finals after the pair landed in the same half of the men's draw.
The Spaniard starts against Australia's Alexei Popyrin, while Serbia's Djokovic plays American Tennys Sandgren.
Swiss eighth seed Roger Federer has also been drawn in the same half as Nadal and Djokovic.
Federer, 39, returns to the Paris clay after missing last year's tournament through injury and will face a qualifier in his opening match, with Djokovic potentially looming in the quarter-finals.
In the women's draw for the tournament that starts on Sunday, Australian world number one Ashleigh Barty starts against 70th-ranked American Bernarda Pera.