Qualifier Liam Broady was beaten in four sets by Czech Jiri Vesely in the first round to leave just one Briton in the French Open men's singles draw.
Broady, 26, was appearing in the Roland Garros main draw for the first time and gave a good account of himself in a 6-2 5-7 6-3 6-2 defeat.
His loss follows Sunday's exits by Andy Murray and Dan Evans.
Britain's last men's singles hope is Cameron Norrie, who faces Colombian Daniel Galan later on Monday.