The Bills opened as a 3 point favorite over the Titans at Nissan Stadium. The line has moved to as low as Titans +1 in some places. A lot of that probably has to do with the fact that it was announced today that Karlos Williams has a concussion. His status for Sunday's game is up in the air. The Bills will probably already be without LeSean McCoy, so they signed Boom Herron today.
The over/under for the game is currently 41.5. That is the lowest total currently on the board.