The Titans and Broncos haven’t played each other since a 13-10 Titans win during Week 14 of the 2016 season to keep their playoff hopes alive. The Broncos starting quarterback in that game was Trevor Siemian which makes it seem like ages ago since Denver has had approximately 32* different starting quarterbacks since that game.
*Actually just four — Brock Osweiler, Paxton Lynch, Case Keenum, and Joe Flacco — but it feels like a lot more.