An early-season division clash with the Indianapolis Colts could end up being the biggest game on the schedule for the Tennessee Titans when we look back on this season in February.
The Titans are coming off of a disappointing loss to the Cleveland Browns but are still in great position to take control of the AFC South.
As for the Colts, they're already in desperation mode. They can't afford to go to 0-3, even in a division that virtually every expert has them winning.
Offensive Game Plan
Both teams enter this game with injuries at important positions, but the Colts may have the worst of it.