After losing their 2020 season to the COVID-19 pandemic, several seniors on the TCU baseball team decided to return and play one more year for the Horned Frogs and head coach Jim Schlossnagle. With a veteran group coming back and young players on the rise, TCU won over 40 games and dominated in Big 12 competition, clinching a share of the regular season title and going unbeaten at the conference tournament in Oklahoma City.
The Horned Frogs entered the NCAA Tournament as the No. 6 national seed and hosts of the Fort Worth Regional with Oregon State, Dallas Baptist and McNeese State.