The Rays are in Buffalo to play the Toronto Blue Jays after getting swept by the Washington Nationals. 21-year-old Luis Patiño faces off against 23-year-old Alek Manoah.
The Rays went down in the top of the first with Wander Franco and Austin Meadows striking out to end the inning.
Bo Bichette singled with one out in the inning and scored when George Springer hit a two-out, two-run home run to put the Blue Jays on top.
The Rays struck out in order in the top of the second, making it five consecutive strikeouts for Manoah.