Week 1: vs. Titans, Sept. 13
Quarterbacks taken 1-2 in the draft have never faced off in their NFL debut, but the Bucs' Jameis Winston and Titans' Marcus Mariota will do just that. Tampa Bay is 2-8 all-time vs. Tennessee, though the Bucs won the last meeting in Tampa in 2007.
Week 2: at Saints, Sept. 20
New Orleans has beaten the Bucs in seven straight meetings — a win here would match the Jets for longest active streak by any Bucs opponent. Four of the past six losses to the Saints have been by a touchdown or less, including both last season.