When the eight-ranked LSU Tigers come to town this Saturday, it'll be the latest in a long line of top 10 opponents to appear on the Syracuse Orange football schedule. Since 2000 alone, Syracuse has faced 20 different teams ranked among the top 10 in the country. Unfortunately, the Orange are 2-18 in those contests, and have been outscored by a final. combined count of 729-271. Those games for your perusal (and hopefully, forgetting thereafter):
| YEAR | OPPONENT | RESULT |
| 2014 | #8 Notre Dame | L, 31-15 |
| 2014 | #1 Florida State | L, 38-20 |
| 2013 | #3 Clemson | L, 49-14 |
| 2013 | at #2 Florida State | L, 59-3 |
| 2012 | #2 USC | L, 42-29 |
| 2009 | #7 Penn State | L, 28-7 |
| 2009 | #5 Cincinnati | L, 28-7 |
| 2006 | at #5 West Virginia | L, 41-17 |
| 2006 | #6 Louisville | L, 28-13 |
| 2005 | at #6 Florida State | L, 38-14 |
| 2005 | at #6 Notre Dame | L, 34-10 |
| 2004 | #8 Florida State | L, 17-13 |
| 2003 | at #4 Virginia Tech | L, 51-7 |
| 2002 | #8 Virginia Tech | W, 50-42 |
| 2002 | #1 Miami (FL) | L, 49-7 |
| 2001 | at #8 Tennessee | L, 33-9 |
| 2001 | at #5 Virginia Tech | W, 22-14 |
| 2001 | at #1 Miami (FL) | L, 59-0 |
| 2000 | #2 Virginia Tech | L, 22-14 |
| 2000 | #2 Miami (FL) | L, 26-0 |
As you'll notice, SU has lost 13 straight games against top 10 teams -- the last win coming against Virginia Tech in 2002.