Syracuse and Louisville enter Friday's game at the Carrier Dome at polar opposites.
The Orange (7-2, 4-2 ACC) are at their highest ranking (No. 13) in the AP Top 25 poll and since they were No. 11 in 1998, when Donovan McNabb was the starting quarterback.
Syracuse is also 13 in the College Football Playoff poll.
Without Heisman Trophy-winning quarterback Lamar Jackson, who is now in the NFL with the Baltimore Ravens, Louisville is winless in the ACC at 0-6 with a 2-7 overall record. Coach Bobby Petrino has lost four recruits who have de-committed in the last few weeks as rumors have swirled about his future at Louisville.