Syracuse, N.Y. -- No. 13 Syracuse football opened as a 21.5-point favorite to beat Louisville on Friday in the Carrier Dome, according to VegasInsider.com.
The Orange (7-2, 4-2 Atlantic Coast Conference) is riding a three-game winning streak into senior night after beating Wake Forest 41-24 in Winston-Salem, N.C., on Saturday. The Cardinals (2-7, 0-6 ACC) haven't beaten a Power-Five program all season, most recently getting shellacked by No. 2 Clemson 77-16 this weekend.
SU's projected margin of victory is one of the program's highest in recent history. If the line holds up, it would mark the first time in 17 years that Syracuse has been favored against a conference opponent by that many points, according to OddsShark.