The Syracuse Orange entered week six with an unexpected record of 2-3. The hopes of a special season seemed to be gone but the Orange still had time to right the ship. Up next were the East Carolina Pirates.
Donovan McNabb made sure that the Orange got off to a fast start in this game. McNabb ran for two first-half touchdowns and hit Quinton Spotwood for a 94-yard touchdown pass. Syracuse went into the half with a 21-0 lead and never let up in the final thirty minutes.
Donovin Darius got an interception to start the second half and the Orange cashed in with a 26-yard Rob Konrad touchdown run.