The Carabao Cup gets serious as Premier League teams, other than those competing in Europe, enter the tournament in round two.
Tuesday night's busy fixture list includes a tasty London derby between West Ham United and League One Wimbledon.
There is an all Premier League clash between Brighton and Southampton, while Crystal Palace, Leicester City, Cardiff, Wolves, Fulham and Huddersfield are also in action.
Most ties kick off at 7.45pm, but Swansea vs Palace starts at 7.30pm, with West Brom vs Mansfield and Stoke vs Huddersfield getting underway at 8pm.