Sunderland have confirmed Tuesday's League One game at Accrington Stanley has been suspended, as a Covid-19 outbreak continues to affect the squad.
It follows the postponement of the Black Cats' past three games - against Shrewsbury, Blackpool and Hull - with this now the fourth in succession.
Sunderland said the decision was made on player welfare grounds, given the volume of positive cases at the club.
The Wearsiders' next game is due to be against Northampton on 2 January.
As per the previous postponements, the English Football League will investigate the circumstances behind the call-off.