At least one new era will begin at the Bet365 Stadium on Saturday (12:30 GMT) when Mark Robins takes charge of his first game since being installed as Potters boss, having watched their 0-0 draw at Burnley from the stands on New Year's Day.
It will be Plymouth's second match since parting ways with Wayne Rooney, with Kevin Nancekivell and Joe Edwards having taken charge of the dramatic 2-2 draw against Bristol City to kick-off 2025.
Argyle remain bottom, effectively five points from safety, but City are too close for comfort, seven points ahead of Plymouth, but having played a game more.