Sheffield Wednesday have won five of their past six away games to climb up to ninth in the table, but they return to Hillsborough on Saturday, where they have won just one of their past seven matches.
Visitors Stoke are winless in their past seven games and have just one victory in eight on their travels, albeit an eye-catching 2-0 success at Blackburn on 6 November.
The Potters have slipped to 17th, just five points above the relegation zone.
Sheffield Wednesday have lost just two of their last 12 league games against Stoke City (W4 D6), though five of their past six home matches in that spell have finished in draws.