Portsmouth continued their impressive home form by beating Middlesbrough 2-1 on Saturday to extend their unbeaten run at Fratton Park to six games (W5 D1).
Pompey have gained 19 points from 12 home games (W5 D4 L3) this season, compared to just seven points from 14 away matches.
Stoke City are unbeaten in their past four Championship matches (W1 D3), following a 1-1 draw at West Brom at the weekend, but are still searching for a first league win under new boss Mark Robins (P2 D2).
Portsmouth have lost each of their past three league games against Stoke City, including a 6-1 defeat in the reverse fixture in October.