Manchester United pair Luke Shaw and Henrikh Mkhitaryan could return from illness and injury respectively.
Phil Jones remains absent with a knee problem, while Wayne Rooney is pushing for a starting spot after impressing off the bench on Thursday.
Stoke midfielder Joe Allen has not trained since last weekend due to a tight hamstring and is a doubt.
Forward Jon Walters could return after an ankle injury but goalkeeper Jack Butland remains sidelined.
MOTD COMMENTATOR'S NOTES
Steve Bower: "Jose Mourinho will be aiming for Manchester United to get close to replicating last weekend's first-half display, while Mark Hughes will be hoping his former club are more in the mode of Thursday's laboured Europa League victory.