Stanford is 5-2 in its last seven matchups with Southern Cal, 4-3 against the spread, including an upset victory over the Trojans down in Los Angeles back in September. But can the Cardinal beat USC twice in one season? We'll find out when the teams meet in the Pac-12 Championship Game Saturday evening at Levi's Stadium.
Point spread: The Cardinal opened as four-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 35.9-30.0 Cardinal
Why the Stanford Cardinal can cover the spread
Stanford has won two games in a row since its loss to Oregon, after outlasting Notre Dame last week 38-36.