The Cubs jumped on top with four first-inning runs Monday at Busch Stadium.
With one out, Kris Bryant singled sharply to right and Anthony Rizzo walked. Willson Contreras followed with a line drive to left, but Tommy Pham came on to make a sliding catch. After Ben Zobrist loaded the bases with an infield hit, Addison Russell sent a 1-2 offering from Luke Weaver into the right-field corner for a double that cleared the bases and put the visitors on top 3-0.
Jason Heyward followed with a double to right-center, making it 4-0.
Veteran lefty Jon Lester gave up a two-out single to ex-Cub Dexter Fowler but followed with a strikeout of Paul DeJong to end the opening inning.