The San Diego Padres have tied the Cardinals 1-1 in the seventh inning on Jedd Gyorko's solo home run.
Gyorko took Michael Wacha's 2-0 pitch 404 feet and into the left field bleachers. It was his third home run of 2015.
So far, Wacha has allowed five hits in seven innings. He has struck out six and walked one.
Cards take 1-0 lead in fifth inning
The Cardinals hold a 1-0 lead over the San Diego Padres through five innings at Busch Stadium.
Jason Heyward led off the bottom of the fifth with a single, and Yadier Molina moved Heyward to third on a hit-and-run into left field.