A pitchers' duel between Cardinals ace Adam Wainwright and Padres' starter Andrew Cashner got its first taste of offense in the fifth inning. It came at the Cardinals' expense.
Alexei Ramirez's one-out single to left field scored Ryan Schimpf, who doubled to start the inning.
The Padres' 1-0 lead snapped Wainwright's streak of 18 1/3 scoreless innings that dated back to his start on July 3, the longest streak of its kind by a Cardinals pitcher this season.
The Padres then doubled their lead thanks to Travis Jankowski's two-out double to left center. Ramirez scored from second before Jankowski was thrown as he tried to advance to third.