Yairo Munoz, the new Cardinal who hit his way onto the opening day roster, will make his first major-league start, coming on opening day at Busch Stadium, complete with a corvette ride and introduction to the red jackets. To make room for Munoz in the lineup, the Cardinals are shifting No. 3 hitter Matt Carpenter to second base and sitting Kolten Wong, the presumptive everyday start at second base.
- Dexter Fowler, RF
- Tommy Pham, CF
- Matt Carpenter, 2B
- Marcell Ozuna, LF
- Jose Martinez, 1B
- Yadier Molina, C
- Paul DeJong, SS
- Yairo Munoz, 3B
- Adam Wainwright, P
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