Vargas' game-winning homer came on a 1-1 curveball from reliever Carlos Villanueva and helped the Twins win their second straight over the Cardinals, after St. Louis won both games at Busch Stadium. The walk-off win was keyed by Joe Mauer connecting on a game-tying solo homer to left field with two outs in the eighth off lefty reliever Kevin Siegrist.
Twins right-hander Mike Pelfrey kept his club in the game, as he gave up just one run on four hits over eight innings. Pelfrey's lone mistake was giving up a solo homer to Jason Heyward with two outs in the seventh.