The Cardinals, 100-game winners for ninth time in franchise history, wrapped up home-field advantage through the NL Championship Series by finishing with baseball's best record. It marks the second time in three seasons that St. Louis can boast of being the NL's best over a 162-game stretch, and the last time, in 2013, the Cards parlayed home-field advantage into a trip to the World Series.
| Gm 1 | Oct. 9 | TBA | NLWC @ STL | TBS |
| Gm 2 | Oct. |