First pitch is scheduled for 6:45 p.m. at Busch Stadium.
Lars Nootbaar will lead off for the Cardinals as they take on his Team Japan teammate and 2021 American League MVP Shohei Ohtani. The Japanese superstar will pitch for the Los Angeles Angels and hit third. In addition to his 4-0 record and 1.85 ERA as a pitcher, Ohtani has seven home runs, five stolen bases and a batting average of .294.
Due to a rule specifically created for him, when Ohtani is removed from the game as the pitcher, he will be allowed to continue as the designated hitter, with a new pitcher taking over on the mound.