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West Virginia vs. Iowa State Prediction, Odds and Key Players for Saturday, Feb. 24 (Target Home Favorite)

Iowa State couldn't overcome the Houston defense on the road, but now returns back to Hilton Coliseum to face the lackluster West Virginia Mountaineers in hopes of improving its standing towards the top of the Big 12 standings.

West Virginia scored a home win as underdogs against UCF, but now must travel to Iowa State, who bolsters one of the two best defenses in the country. Can the Mountaineers stay within a massive spread, or will Iowa State put up a big number and outpace a bottom feeder in the conference?

Here's our best bet for Saturday's Big 12 matchup:

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